Sweat spot and coffee spot can be differentiated from clinical manifestations, etiology and treatment. 1. Clinical manifestations (1) Sweat spot: it is mostly found in young and middle-aged men, and it occurs in sebaceous gland-rich areas, such as face, neck and front chest. The lesions are centered on the pores, and the boundaries are clear, and the neighboring lesions can be fused with each other, and there is no self-conscious symptom in general. (2) Café-au-lait spots: they are mostly found in the trunk, with clear boundary and smooth surface, appearing at birth or after birth, and their number increases throughout the childhood, and they will not subside on their own. 2. Etiology: Sweat spot is mainly caused by human parasitic bacteria Malassezia, and coffee spot is hereditary disease. 3.Treatment (1) Sweat spot: topical medicines such as clotrimazole cream, bifonazole solution, etc., with a course of 2~4 weeks, or sodium thiosulfate solution can be chosen. (2) Café-au-lait spots: traditional treatments include freezing, excision, etc., but the efficacy is uncertain and often leads to serious complications such as permanent pigmentation changes. In order to distinguish sweat spot and coffee spot more accurately, you should go to regular hospitals and take appropriate treatment after diagnosis by professional doctors as prescribed by doctors.