Patients are very painful in the advanced stage because there is no way to treat effectively, so in the advanced stage the cancer cells have spread to the whole body, there will be obvious bleeding and pain, and the ascites will be more serious, and cholangiocarcinoma will usually cause the state of death due to body failure. Surgery is to remove the tumor, but it is not effective for advanced patients. Radiation therapy can improve the survival rate, especially for tumors that cannot be removed, and it can prolong the life of patients. The stool will be grayish white, and the bile ducts are usually very enlarged, accompanied by liver damage and blood in the stool.