Since the world’s first laparoscopic cholecystectomy was performed in 1987, laparoscopic cholecystectomy has become the gold standard for cholecystectomy and has been accepted by a wide range of patients and physicians. Increasingly less trauma, less pain, and achieving rapid recovery and cosmetic results are the goals pursued by laparoscopic surgeons. With the continuous maturation and development of laparoscopic technology, laparoscopic cholecystectomy has evolved from the initial four-hole to the current conventional three-hole technology, to the single-hole laparoscopic cholecystectomy through the umbilicus, which is currently performed in only a few hospitals in China. The single-hole laparoscopic technique via umbilicus is a new type of minimally invasive surgery that has just been carried out in domestic clinics, which is a kind of “invisible” surgery and is the evolution of minimally invasive surgery to scarless and natural cavity surgery. The single-port laparoscopic cholecystectomy is performed through the umbilical port, which is an inherent channel of the human body, and a 50px incision is made close to the lower edge of the umbilical port, and the incision is covered by the umbilical crease after healing, thus having a satisfactory cosmetic effect and basically achieving no scar on the body surface. Single-port laparoscopic surgery is performed by placing three puncture tubes in one incision and placing surgical instruments through the operating orifice to complete the operation. The angle between the instruments is changed from three holes to one hole and the angle becomes zero in parallel, which makes the operation much more difficult. At present, not many hospitals are performing this surgery, but with the skillfulness of the technique and the renewal of the instruments, single-hole laparoscopic cholecystectomy will become the preferred choice for cholecystectomy, and the era of minimally invasive surgery without scars is coming. What are the advantages and disadvantages of single-port laparoscopic cholecystectomy? The biggest advantage of single-port laparoscopic surgery through the umbilicus is firstly, there is no obvious surgical scar on the body surface, which has a satisfactory cosmetic effect, which is especially favored by female patients; secondly, it can reduce postoperative pain and shorten the recovery time and hospitalization days. Single-port laparoscopic cholecystectomy is more expensive than general laparoscopic surgery because it relies on highly sophisticated equipment such as turnable instruments and ultrasonic knives, and there is no angle between the operating instruments which makes the surgery difficult to carry out widely for the time being. Which patients are suitable for single-port laparoscopic cholecystectomy? Laparoscopic cholecystectomy is now the first choice for patients with gallbladder removal, but which patients are suitable for single-port laparoscopic cholecystectomy? Patients with gallbladder polyps, chronic cholecystitis with gallbladder stones and benign gallbladder tumors are more suitable, but patients with gallbladder full of stones, atrophic cholecystitis and severe adhesions around poorly defined gallbladder structure are not suitable for single-port laparoscopic surgery, and some patients even need traditional open surgery. At present, we start the surgery with a laparoscopic exploration through the umbilical port, which is only done in patients with clear anatomy of the gallbladder and no obvious adhesions, so as to ensure the safety and increase the success rate of the surgery.