The causes of shingles 20+ days of yellowish discharge and numbness in the hands are related to infection as well as involvement of nerves, respectively. Herpes zoster is caused by the patient’s infection with varicella zoster virus, which can involve the patient’s skin and nerves. The fluid in the clusters of blisters that appear in patients with herpes zoster is normally clear. If yellowish water flows, it is mostly related to infection and requires prompt antiseptic and antibacterial treatment in the hospital. In addition, the blisters caused by the herpes zoster virus will be distributed along the unilateral innervation area, if the patient’s arm part of the blisters, the unilateral arm nerve will be damaged, resulting in hand numbness phenomenon. When herpes zoster patients appear yellow water and hand numbness phenomenon is more serious, it is recommended to go to the hospital in time for treatment.