In general, non-invasive DNA report cards are categorized as low risk and high risk. Noninvasive DNA accurately detects the three major chromosomal disorders Down syndrome (T21), Edward’s syndrome (T18), and Patau syndrome (T13) with detection rates of 99%, 97%, and 91%, respectively. The representation of the results is similar for each report, and the noninvasive DNA test results are a proportional data, which takes the form of 1:n, with 1 being the numerator and n being the denominator. the greater the number of n, the better. Typically, the value of n for low-risk individuals is in the thousands. Non-invasive DNA, if it is low risk, then the risk of the fetus having Down syndrome is almost none is relatively safe, if non-invasive DNA shows high risk, then the possibility of the fetus having the three major chromosomal disorders is more likely. If the non-invasive DNA report is high risk, further amniocentesis is recommended. Amniocentesis is the gold standard of testing.