Lumps in the anus are treated with antibiotics if they are caused by a perianal abscess. In the case of perianal lumps caused by localized thrombosis, treatment to eliminate swelling and pain is sufficient. If it is caused by sebaceous cysts, surgical treatment is needed. 1. Perianal abscess: most of the perianal abscess is formed because of the blockage of the perianal glands and infection, which will cause obvious pain and anal area lumps, so it can be either local incision and drainage, or antibiotic treatment, such as penicillin, cefixime and so on. 2. Perianal blood clots: If there is a local blood blockage around the anus, blood clots or blood clots caused by bleeding, etc. can also lead to the appearance of lumps and cause pain, you can take to eliminate swelling and pain medication to effectively alleviate the discomfort, such as ibuprofen delayed-release capsules, diclofenac sodium and so on. 3. Sebaceous cysts: local sebaceous glands in the perianal area, if there are cysts, will also directly lead to the perianal area to appear localized lumps, at this time there is no obvious efficacy of drug treatment, so it is recommended to the hospital as soon as possible to carry out local incision and debridement of the way to effective treatment. After the occurrence of anal lumps, should be based on the specific causes of targeted treatment, it is recommended to deal with under the guidance of the doctor.