Delayed excretion of bromosulfophthalein is an indicator of abnormal liver function with increased serum alkaline phosphatase activity, delayed excretion of bromosulfophthalein, decreased plasma albumin, prolonged prothrombin time, and elevated indirect bilirubin abnormal globulin. Abnormal liver function is when the liver is damaged by certain pathogenic factors that can cause damage to the morphological structure of the liver and abnormal metabolism of liver function. Differential diagnosis of delayed excretion of bromosulfonephthalein: 1. Various viral hepatitis, fatty liver, cirrhosis, and severe liver disease are the most common causes of abnormal liver function. 2. Infection with parasites (Schistosoma haematobium, Toxoplasma gondii, Amoeba), leptospira, bacteria, and viruses can all cause liver damage; among them, viruses are especially common. Such as: liver encystment, liver bacterial infection, hepatitis B, etc., is also the cause of liver function abnormalities. 3, bile duct obstruction, such as stones, tumors, roundworms, etc. make bile stagnation, such as too long, can cause liver ischemia due to the damaging effect of stagnant bile on liver cells and the compression of blood sinusoids by dilated bile ducts in the liver, causing hepatocyte degeneration and necrosis, which becomes the cause of abnormal liver function. 4, chemical poisoning can often destroy the enzyme system of hepatocytes, causing metabolic disorders, or inhibit the oxidative phosphorylation process and reduce ATP production, leading to degeneration and necrosis of hepatocytes, resulting in abnormal liver function; some drugs, such as chlorpromazine, para-aminolevulinic acid, isoniazid, certain iodamide drugs and antimicrobials, can cause liver damage in a few people even at therapeutic doses, and are the most common transient liver function The cause of abnormal liver function, which may be related to allergies, can generally be restored within a few days after stopping the drug. 5, blood circulation disorders, such as in chronic heart failure, causing liver stasis and hypoxia, is also one of the causes of abnormal liver function. 6, genetic defects, some liver diseases are hereditary diseases caused by genetic defects. Hereditary hemochromatosis, cystic fibrosis, a1-antitrypsin deficiency and Wilson’s disease are the most common and important congenital liver diseases that may lead to abnormal liver function.