At present, corneal endothelial damage is difficult to regenerate, generally only through the surrounding normal cell migration repair, corneal endothelial loss patients can feasible corneal transplantation treatment to improve vision. First of all, for the corneal endothelial injury can not regenerate this problem, need to make clear that the number of corneal endothelial cells is limited, the current corneal injury is more difficult to regenerate. The corneal endothelium has the function of keeping the cornea dehydrated and transparent, so when it is severely decompensated, herpetic keratitis may occur, which will seriously affect the patient’s vision. Although the corneal endothelium is not regenerative, when it is damaged within a certain limit, it can be filled in by the migration of peripheral endothelial cells, which will not affect the vision too much. Before undergoing corneal myopic laser, cataract ultrasonography, etc., the examination of the number of corneal endothelial cells is a mandatory item, so as to avoid the occurrence of severe loss of compensation in the postoperative period. It is recommended that patients with corneal endothelial loss should seek prompt medical attention to evaluate their condition and follow the doctor’s instructions for treatment.