A woman’s natural fertility begins to decline after the age of 35, and although many women are still fertile after the age of 40, typically, most women lose their fertility completely years before menopause. Although assisted reproductive technology (ART) can solve fertility-related problems for many infertile couples, it cannot make up for all families. The advanced age of women undergoing IVF and the decrease in ovarian reserve function are the main reasons for IVF failure. All women should be aware of the objective fact that advanced age causes a decrease in fertility, and obstetricians and gynecologists have an obligation to educate every woman who intends to have a baby after the age of 35 about the relevant science and inform them about the characteristics of their body’s biological clock. 1. Women over 35 years of age need to know the fact that their chances of conception are significantly lower than those of the younger age group. Women over 40 years of age have only a 1 in 100 chance of conception per menstrual cycle, and if they have not conceived after 6 months of active attempts, a more active approach is to consult a reproductive medicine specialist and receive the necessary medical assistance. 2. For women over 40 years of age, the doctor is obliged to inform the older mother about the risks of pregnancy, including the relatively high risk of miscarriage, the increased risk of pregnancy complications, such as surgical delivery, diabetes, intrauterine growth restriction and low birth weight babies, and the need for screening for certain diseases, such as diabetes and hypertension, before conception. 3. If conditions permit, both partners should undergo a comprehensive medical examination that includes a preconception checkup. Obstetrics and gynecology should include: gynecological examination, cervical cytology screening (currently mainly TCT), ultrasound of the uterus and both adnexa, and screening for high-risk HPV virus and TORCH testing is also recommended. 4. Take one 0.4mg of folic acid daily starting three months before planned pregnancy until three months after successful conception. In case of unplanned pregnancy and no early folic acid supplementation, as long as women are not extremely paranoid or severely malnourished, they should not overly panic and just start taking it in time. 5. For women with regular menstruation, maintaining a regular sex life (2-3 times/week) from the last clean period can help increase the chance of conception. The 6 days before ovulation is medically defined as the “conception window”, if you can maintain a frequent sex life within these 6 days / 1-2 days will get the maximum chance of conception. 6.If sex is not so frequent, or if the couple lives in two places or one of them travels a lot, it is recommended to master some methods to predict ovulation, such as measuring basal body temperature and using ovulation test strips, which will be helpful to improve the conception rate. 7. Once you have successfully conceived, you should have prenatal checkups as early as possible. Pregnancy in women over 35 years old is medically known as high-risk pregnancy, which increases the risk of delivering a fetus with chromosomal abnormality/abnormality. This can help detect chromosomal abnormalities early). 8, healthy diet, exercise and regular routine need not be stressed, whether or not to have children, women who have been able to do so will benefit for life. For example, avoid smoking, excessive alcohol consumption, excessive coffee, drug use, exposure to toxins or harmful chemicals. 9, about the mode of delivery: advanced age is not an absolute indication for cesarean delivery, it is recommended to adopt a good lifestyle of healthy diet and regular exercise before pregnancy, and insist on exercise during pregnancy to control weight and avoid oversized fetus, if there is no contraindication for vaginal delivery, advanced maternal age can also be delivered smoothly. 10. Finally, it should be noted that advanced age fathers appear to be at increased risk for spontaneous abortion, certain autosomal dominant genetic disorders, autism spectrum disorders, and schizophrenia. Men should be counseled for these possible risks if they are older than 40 years, although this risk is small.