There are no confirmed effective targeted therapeutic drugs for novel coronaviruses. The “Diagnostic and Treatment Program for Pneumonia Infected by Novel Coronaviruses (Trial Sixth Edition)” (hereinafter referred to as the “Diagnostic and Treatment Program”) recommends α-interferon, Lopinavir/Ritonavir, Ribavirin, Chloroquine Phosphate, and Abidol. However, all of these drugs are in clinical trials or in the clinical research phase. Many of these drugs carry a risk of liver injury. Below we describe the risk of liver injury and the corresponding management measures that can be taken for these drugs. 1, the mechanism of action of antiviral drugs The mechanism of action of antiviral drugs recommended in the “Diagnostic and Treatment Program” mainly includes: regulating immune function, preventing viral invasion of cells, and inhibiting viral replication. 2.Risk of liver injury of antiviral drugs 3.Coping strategy of liver injury of antiviral drugs 4.Commonly used liver-protecting drugs (1) Liver-protecting and enzyme-lowering drugs Diphenhydramine: mainly used for the treatment of viral hepatitis. It is effective for acute hepatitis and mild chronic hepatitis, but less effective for moderate chronic hepatitis and cirrhosis. It can significantly reduce the level of alanine aminotransferase, and its effect on aspartate aminotransferase is general. Dicyclomine: similar in structure to biphenyl dibenzoate and has similar indications. These drugs should be taken continuously and tapered off gradually, not stopped abruptly. (2) Relief of cholestasis ursodeoxycholic acid: mainly used for cholestatic liver disease and chronic liver disease with intrahepatic cholestasis. Adenosylmethionine: chronic liver disease, intrahepatic adenosylmethionine synthesis is reduced, exogenous supplementation, can play a certain protective role in liver injury, cholestatic liver disease also has a certain effect. (3) Hepatoprotective and detoxifying drugs Reduced glutathione: It mainly exists in the cytoplasm and plays a role in many cellular biochemical functions, and can also be combined with free radicals in the body through sulfhydryl groups to promote the formation of easily metabolized low-toxicity compounds, and it has a detoxifying effect on some of the exogenous substances. Commonly used in various types of liver disease and detoxification of drugs. Thiopronin: Thiopronin is a kind of drug containing free sulfhydryl group, which can prevent liver injury caused by some chemicals and drugs, and inhibit the accumulation of triglyceride in chronic liver injury. It also improves liver function by protecting liver mitochondrial structure. It has detoxification effect on some exogenous substances by binding with free radicals. It is often used to improve liver function in patients with chronic hepatitis B. However, this product has more adverse reactions. (4) Hepatocyte membrane repair drugs Polyene phosphatidylcholine is a kind of phosphatidylcholine extracted from soybean oil, most of which is the essential phospholipid 1,2-dioleoylphosphatidylcholine that the human body cannot synthesize by itself. It can accelerate the regeneration and stabilization of liver cell membrane, inhibit lipid peroxidation, and inhibit collagen synthesis. It is used to assist in the improvement of toxic liver injury (e.g., liver injury caused by drugs, poisons, chemicals and alcohol, etc.) as well as loss of appetite and right upper abdominal pressure in patients with fatty liver and hepatitis. However, it is contraindicated for those who are allergic to soy protein. (5) Anti-inflammatory drugs Glycyrrhizic acid preparations: the drug has an adrenocorticotropic hormone-like effect, with anti-inflammatory, reducing the role of immunopathological reactions. It also has the function of protecting liver cell membrane and improving liver function. Clinically, it is commonly used in chronic viral hepatitis to improve liver function. Currently commonly used are compound glycyrrhizin, diammonium glycyrrhizinate, magnesium isoglycyrrhizinate. However, it is contraindicated in patients with severe hypertension and hypokalemia. (6) Others Silymarin: It can stabilize the liver cell membrane, protect the liver cell enzyme system, and remove the active free radicals in the liver cell, so as to improve the detoxification ability of the liver. It is commonly used in the recovery of abnormal liver function in acute and chronic hepatitis and fatty liver.