In the early stages of Trichophyton rubrum infection, if the area of infected skin is small, it can be eradicated simply by using topical medications, such as the many topical antifungal preparations available on the market, miconazole, ketoconazole, terbinafine, ciclopirox, etc., which in most cases can completely cure the early Trichophyton rubrum infection. However, as time goes on and the area of infection expands, some patients will have their symptoms remitted or reduced on their own without treatment, and after a longer period of time it is difficult to completely distinguish between healthy skin and infected skin. There are also some infections that cause keratinization and thickening of the keratin, and it is difficult to penetrate the infected area of the germ with topical drugs alone, and if the infection reaches the nails, it is even more difficult for topical drugs to penetrate the If the nail is infected, it is even more difficult for the topical medication to penetrate the infected area, and oral medication is required to completely remove the ringworm.