Lymph nodes and nodules have the following differences: 1. Lymph nodes are present in the body itself and are congenital, while nodules are caused by abnormal lesions in body tissues and organs, which lead to their appearance later in life. 2. If lymph nodes become enlarged, they are stimulated by surrounding inflammation or malignant tumors through metastasis, resulting in enlarged lymph nodes, while nodules appear or increase in size are caused by local lesions. If it is caused by malignant tumor, the original disease must be treated and the lymph nodes may need to be cleared by surgery. If the nodes are benign and small, they do not need special treatment and the effect of medicine is not great, but if the nodes are large or painful, they can be treated by surgical removal.