Leukocyte 0.4×10^9/L belongs to severe leukopenia, which requires active identification of the cause of the disease, application of drugs to elevate leukocytes or treatment of the cause of the disease and complications.
There are many causes of leukopenia, various cytotoxic drugs, benzene and other toxic substances, radiation, leukemia, acquired immunodeficiency diseases, hypersplenism and other factors can cause a significant reduction in white blood cell count.
1. If there is such a serious reduction of white blood cell count, it is necessary to actively treat the primary disease, such as aplastic anemia to be oral treatment with cyclosporine, and at the same time to carry out aseptic isolation, the use of hematopoietic growth factors, such as human granulocyte stimulating factor to enhance white blood cell therapy.
2. If the patient has fever and other infectious symptoms, it is necessary to do bacterial culture of blood, sputum and other secretions and drug sensitivity test, and use broad-spectrum antibiotics as early as possible to fight infections, such as levofloxacin and so on.
The value of white blood cells is normally above 4.0×10^9/L, below 2.0×10^9/L is severe leukopenia, while 0.4×10^9/L is extremely severe leukopenia, which will cause a total collapse of the immune system and lead to the emergence of severe sepsis and infectious shock. Diagnosis and treatment of specific diseases should be carried out under the supervision of a physician.