Cold precipitation, which is rich in coagulation factor VIII, fibrin, proangiogenic pseudohemophilic factor, fibrin-binding protein, and coagulation factor XIII, is often used to treat congenital or acquired bleeding disorders, such as severe trauma, burns, leukemia, liver failure, and other fibrin deficiencies, by injecting cold precipitation, which can Cold precipitation can significantly improve the symptoms and allow the bleeding to stop quickly. For many congenital diseases, especially hemophilia, cold precipitation can be used for adjustment. Hemophilia, a disease that manifests itself as a deficiency of clotting factors, can be supplemented with cold precipitation. There is also hemophilia A in children and adults, which is the main direction of treatment.