Cervical spondylolisthesis hand numbness is mainly due to nerve root irritation and compression, can be applied under the guidance of the doctor pain medication, nutritive nerve medication, dehydration drugs. 1. Painkillers: When cervical osteophytes cause hand numbness, non-steroidal anti-inflammatory and analgesic drugs such as celecoxib and fenbendazole can be applied to relieve pain symptoms and reduce inflammatory reactions at the nerve roots to alleviate the symptoms of numbness and discomfort. 2. Nutritional nerve drugs: hand numbness symptoms are mostly caused by nerve root stimulation, compression and damage, can be treated by oral vitamin B1, vitamin B12, methylcobalamin and other nutritive nerve drugs, which can help promote the recovery of nerve function, and then alleviate the numbness of the hand, but usually need to be followed by the doctor’s instructions for long-term use. 3. Dehydration drugs: Mannitol, glycerol fructose and other drugs can be used to treat nerve root dehydration, which is helpful to reduce the edema of the nerve root and relieve the numbness of the hand caused by nerve compression. When cervical spondylolisthesis causes hand numbness, it is necessary to consult a doctor in a timely manner, under the guidance of specialists to actively carry out appropriate treatment, which will help to alleviate the uncomfortable symptoms as soon as possible.