Hands burning like chili peppers may be caused by food factors, stings, septic infections, and exposure to chemicals. 1. Food factors: cutting chili peppers when cooking, chili peppers contain capsaicinoids and other substances, stained on the hands, may cause local skin irritation, which will lead to burning sensation of the hands, carefully scrubbed with white wine or vinegar, and then rinsed with water, the symptoms will be alleviated. 2. Stings: Hands accidentally stung by hornets, scorpions and other venomous insects, there will be a burning sensation or severe pain, usually accompanied by redness and swelling of the skin and other symptoms, and in severe cases, it will be secondary to bacterial infection. 3. Purulent infection: the skin of the hand after a break is not treated, may induce purulent infection, the infection is serious, it will cause burning sensation, may also be accompanied by pus, swelling, stinging and other symptoms. 4. Contact with certain chemicals: unintentional contact with certain chemicals, such as strong acid (hydrochloric acid, sulfuric acid, nitric acid, etc.), strong alkali (such as kerosene, etc.), damage to the skin can also appear hand burning discomfort. If your hands burn like chili peppers and are accompanied by other abnormalities, it is recommended that you seek medical attention for examination and treatment to avoid adverse effects.