Generally taking rifampicin and isoniazid can drink more water, can reduce the drug stimulation, reduce the chance of adverse reactions. Rifampicin and isoniazid are both anti-tuberculosis drugs, and their combined use in clinical practice can treat a variety of tuberculosis in the primary and secondary treatment. In general, taking rifampicin and isoniazid can drink more water, mainly because these two drugs are excreted through the kidneys, this time appropriate to drink more water to a certain extent can reduce the concentration of drugs in the urine, promote the absorption and metabolism of drugs. Thus reducing the stimulation caused by the drug to the kidneys. If the renal drug concentration is too high, it will aggravate the metabolic burden of the kidneys, which is more likely to cause adverse reactions such as elevated serum urea and uric acid, renal insufficiency and interstitial nephritis. In addition, abdominal pain, nausea, headache, fever and other discomforts may occur. In conclusion, patients must take rifampicin and isoniazid under the guidance of a doctor, strengthen the management of daily life, and go to the hospital in time if any obvious discomfort occurs.