Walking like stepping on cotton is a body sensory disorder that may be a subacute joint degeneration of the spinal cord. The disease is a neurodegenerative disease caused by vitamin B12 deficiency, and the lesions mainly involve the posterior and lateral spinal cords and peripheral nerves, and most patients develop the disease after middle age. In the early stage, patients may experience weakness, stiffness, clumsy movements and unstable walking in both lower extremities, and may also experience a sensation of stepping on cotton, followed by abnormal sensation in the ends of the fingers and toes, which may manifest as symmetrical tingling, numbness and burning sensation, and may also experience impaired vibration and position sensation in both lower extremities. A few patients may develop glove and sock-like sensory loss. Some patients may also develop psychiatric symptoms, which may manifest as irritability, depression, hallucinations, and cognitive dysfunction, and the treatment of the disease is mainly early high-dose application of vitamin B12.