Neonatal cholestasis syndrome may be caused by infection, congenital developmental abnormality, etc. It can be relieved by medication and surgery. 1. Infection: Cholestasis syndrome in newborns may be caused by infection of the liver, gallbladder and other tissues, which can be treated with anti-inflammatory drugs under the guidance of the doctor according to the actual situation of the child, such as roxithromycin and clarithromycin, etc. Hepatoprotective drugs, such as ursodeoxycholic acid, etc., can also be used. 2. Congenital developmental anomalies: when the child has congenital developmental anomalies, such as congenital biliary atresia, liver developmental anomalies and other diseases, can also cause cholestasis, after identifying the cause of the disease, you can consider treatment through surgical methods, such as jejunostomy, liver transplantation, and so on. It is recommended to seek prompt medical attention in the presence of neonatal cholestasis and proper treatment under the guidance of a doctor.