Colonic tingling is most often caused by colitis, and in the case of chronic non-specific ulcerative colitis or Crohn’s disease, it mostly manifests as pain in the colonic area and constipation, diarrhea, or alternating constipation and diarrhea, as well as mucopurulent stools, and mostly requires treatment with salicylic acid salazosulfadiazine or mesalazine. The common inflammation of the colon is characterized by local pain, diarrhea, and rarely mucopurulent stools. Colon polyps rarely present as colonic stabbing pain, but if they are progressively larger or have a tendency to become malignant, they can be accompanied by colonic stabbing pain. Right hemicolectomy tumor may present with pain, mass, weakness, emaciation and anemia, while left hemicolectomy tumor may present with pain, mucopurulent stool and intestinal obstruction, and the stabbing pain in colonic pre-excitation syndrome is usually accompanied by diarrhea. If the symptoms of colonic stabbing pain appear, it is necessary to do colonoscopy in time and actively treat it after clear diagnosis.