The possible causes of vesicles and bleeding on the glans are: 1. Local mechanical or chemical stimulation leads to mucosal loss and vesicles and bleeding, such as excessive friction of the glans with masturbation, resulting in mucosal loss, vesicles and bleeding or the use of irritating chemical solutions, such as lotions containing alcohol or the direct stimulation of alcohol components, resulting in local mucosal burning and vesicles and bleeding. 2. The actual fact is that you can get a lot more than just a few of these. If you are infected with mycoplasma, chlamydia, etc., you can have local vesicles, bleeding and yellow purulent secretions, often with a history of unclean sexual contact.