Heartburn and dry mouth 2 hours after the end of a meal on quadruple therapy is considered to be related to possible incomplete sterilization, side effects of quadruple medication and digestive disorders. Generally, you need to apply acid-suppressing and stomach-protecting medication. 1. Incomplete sterilization: Helicobacter pylori infection itself will have heartburn, dry mouth, stomach bloating and other symptoms, the routine application of quadruple therapy, the end of the treatment course, if the bacteria are not completely killed, after meals, there will also be heartburn, dry mouth symptoms, generally should be adjusted to continue antibiotic sterilization treatment. 2. Side effects of the quadruple drugs: because the stomach quadruple drug species have antibiotic drugs, such as amoxicillin, clarithromycin, metronidazole, there will be a certain damage to the gastric mucosa, after eating and drinking there will be a certain amount of stimulation of the mucosa, there will be heartburn after meals, dry mouth symptoms. You can apply acid-suppressing and stomach-protecting drugs, such as omeprazole, which may cause nausea, headache, rash, abdominal pain and other adverse reactions after oral intake. 3. Digestive tract diseases: such as reflux esophagitis, chronic gastritis, peptic ulcer, digestive tract tumors and other diseases. Generally, acid-suppressing and stomach-protecting medicines are applied for treatment, or surgical treatment. All of the above drugs need to be applied under the guidance of a doctor, not self-medication, if the end of the quadruple therapy 2 hours after meals heartburn and dry mouth, it is recommended to go to the hospital, under the guidance of the doctor early formal treatment.