The two data that are inseparable from preterm miscarriage are progesterone and HCG, which we have been in contact with since the beginning of pregnancy preparation, and we should be familiar with what they are and what they do, but after pregnancy, especially when preterm miscarriage occurs, mothers-to-be are confused again. What exactly is the relationship between progesterone and HCG? 1, HCG, progesterone and miscarriage of the “triangle relationship” after a successful pregnancy, we go to the hospital to check the two data often seen is progesterone and HCG, the doctor is also very important to these two data. Is a bad doubling of HCG or low progesterone a problem of the mother or of the fetus? The answer is that it could be both. And both maternal and fetal problems can lead to miscarriage. Let’s discuss the relationship between these three situations below. It is very rare to have a normal progesterone but a bad HCG doubling. Because HCG promotes the production of progesterone, if HCG is bad, progesterone is usually bad as well. We will explain the following two situations: 1. Progesterone is normal, but HCG doubling is “relatively” bad. What does it mean? It means that when you go to test one day, the value goes up but does not reach the multiplier, it’s not as good as a hundred or two hundred, that’s relatively bad. If your HCG is already tens of thousands, then the doubling is not so fast and the speed will drop, which is normal. 2, progesterone is normal, HCG doubling “absolutely” bad. Absolutely not good, is the value in a range, let’s say 8 days, only doubled, this situation is not very good. Many hospitals now only supplement progesterone, but rarely supplement HCG, because low HCG is likely to be bad for the embryo itself, which is not very valuable to preserve the pregnancy. If the HCG does not double, but decreases, and the progesterone is also decreasing, the doctor will suggest you to keep the fetus first, and if there is no improvement after taking the fetus preservation measures, you will also be advised to give up as soon as possible and have an abortion. In this case, it is very likely that the embryo itself is not good and there is no point in keeping the fetus. If you force the fetus to be preserved, even if the fetus is successfully preserved, the fetus will face more tests in the later pregnancy, and may even suffer from fetal abortion, which will increase the risk of the mother-to-be when she has an abortion later. The first thing to talk about is HCG, human chorionic gonadotropin, many people often miss the word or reverse certain words, but it does not matter, who knows what it is. Some pregnant moms are familiar with it because they often go to the hospital to have their blood and urine tested for this value. HCG starts to be produced by the body six days after pregnancy, when the fertilized egg is ready to be laid, and it stimulates the body to produce progesterone. Progesterone is about to ensure that the internal environment of the uterus is stable and minimally disturbed by external forces, which also protects the embryo. So how is HCG produced again? Actually, when the fertilized egg is in bed, it will extend its dendritic tentacles and grab the uterine wall, these tentacles are the villi, which will form the early placenta. When the placenta is not mature, these hairs become more numerous and attach to form a thin membrane. These membranes are gradually filled with blood vessels, which become the initial connection between the mother and the embryo for nutrients and metabolic waste. The growth of these hairs is what we call doubling. Generally speaking, HCG doubles every other day in the early stages, so there are no people who take HCG tests every day, but usually every other even numbered day, let’s say 2, 4, 6 or 8 days. HCG also has a very important role to play, which is to reduce the rejection of the pregnant mother. A parasite grows on your body and normally the body’s immune system is going to attack it, but HCG confuses the mother and tells them it’s safe and it’s your own, so the body’s immune system doesn’t kick in. HCG and progesterone work synergistically to give nutrients to the embryo on one hand and keep it safe on the other, so one cannot be missing. a bad doubling of HCG may delay the development of the embryo or even stop it because of lack of nutrients; not enough progesterone will make the embryo unstable in bed, causing bleeding or even miscarriage. However, low HCG and progesterone values do not necessarily lead to miscarriage, but the chances are higher. Once bleeding occurs, you should go for a test, and if you have a history of bad pregnancy before, you can monitor it just in case. Note: Not all bleeding is miscarriage. There are some issues worth noting: first of all, the brown discharge, some people think it is bleeding and go to the hospital to find a doctor to prescribe progesterone to eat, in fact, it is not the case, the brown discharge represents the previous bleeding, most likely caused by the trauma of the time of the birth, later with the delayed discharge of vaginal discharge, very normal. Pink, bright red, non-sticky, heavy bleeding or continuous bleeding is the only thing that needs to be taken into account if it is a miscarriage. This brown discharge usually has a small amount for two or three days and then it passes and does not come back. Knowledge extension: about progesterone to preserve the fetus The use of large amounts of progesterone in early pregnancy can increase the risk of malformation of the fetal spine, anus, limbs and other parts of the body by 8 times. If synthetic progesterone is used (e.g., norethindrone has androgenic effects), about 18% of women have masculinized fetuses. And the use of progesterone under normal conditions of progesterone deficiency does not pose a risk, so we must understand progesterone correctly, the different factors of miscarriage correctly, and the correct understanding of fetal preservation to avoid doing bad things with good intentions. What is the correct way to supplement progesterone? First of all, we must find out whether there is a lack of progesterone. The lack of progesterone can be confirmed by laboratory tests or by measuring the basal body temperature. For those who are indeed luteal deficient, progesterone can be injected from 3-4 days after the basal body temperature rises in order to conceive, and used uninterruptedly for 9-10 weeks until the mother can naturally produce progesterone.