There is no such term as vascular nerve headache in medicine, which generally refers to vascular headache, such as migraine. Drugs used to treat migraine include non-steroidal anti-inflammatory drugs (NSAIDs), ergot-type preparations, treprostinil, benzodiazepines, etc. The treatment of drugs should follow the principle of individualization, and there is no so-called “special effect drug”, and the appropriate drugs should be used according to the doctor’s instructions. Non-steroidal anti-inflammatory drugs such as ibuprofen, diclofenac sodium, etc., can alleviate the patient’s headache; ergot preparations such as ergotamine tartrate, dihydroergotamine, etc., for patients with persistent attacks; traptans such as Maprotan, etc. can be used for patients with moderate to severe, heart disease, pregnant women are prohibited from using the drug; diazepines such as diazepam are often used in patients with insomnia. Since the indications, contraindications and adverse reactions of different drugs are different, doctors will choose the most suitable drug for treatment according to the severity of the patient’s condition and the therapeutic effect. Migraine patients should follow the doctor’s instructions to standardize the use of drugs, avoid blind self-medication, so as not to cause adverse reactions.