Decreased corneal perception causes reduced transients and affects tear film reconstruction. On the one hand, decreased corneal perception decreases the nerve impulses transmitted from the cornea to the brain system via the reflex arc, resulting in a decrease in nerve impulses transmitted from the brain down to the lacrimal gland and causing a decrease in basal tear secretion. On the other hand, when corneal perception is diminished, the corresponding transient frequency decreases because transient frequency is positively correlated with corneal perception, and transient is the basis of tear film reconstruction: each time you blink, the transient action distributes tear mucin evenly on the corneal surface, and also distributes the aqueous and lipid layers evenly on the corneal surface, completing tear film reconstruction. A decrease in the number of blinks leads to enhanced tear evaporation, which affects the uniform distribution of mucin on the ocular surface, thus preventing the aqueous and lipid layers from adhering well and affecting tear film reconstruction. Reduced corneal perception is a clinical symptom of exposure keratitis. Exposure keratitis commonly occurs in a variety of lesions with incomplete lid closure, resulting in impaired corneal exposure and transient eye movements, and corneal epithelial damage due to inability of tears to wet the cornea properly. How to effectively prevent reduced corneal perception? Patients with this disease are extremely uncomfortable due to corneal exposure. It is important to prevent corneal dryness at all times while treating the primary disease, such as making sure to apply plenty of antibacterial eye ointment before sleep to prevent corneal dryness and infection. If necessary, the doctor can temporarily suture the eyelid to leave a slit in the center of the lid to look at things, while keeping the cornea moist. Medication 1. moisturizing drops and ointments. 2. Antibiotics (if the corneal epidermis is damaged). 3.Eye drops with autologous serum – extracted from the patient’s own blood, not available in every hospital, this is the method that doesn’t work after all methods have been exhausted, success rate varies from person to person. Surgical treatment 1. Amniotic membrane transplantation: (1) Amniotic membrane retrieval and preparation: Amniotic membrane is taken from fresh placenta delivered by caesarean section or aseptically by normal delivery. The mother must be serologically tested before delivery to exclude the presence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis, and the birth canal is free of gonorrhea and chlamydia infection. Under aseptic operation, the blood on the surface of the placenta was rinsed with sterile saline, then soaked in antibiotic solution for 5-10 min, the amniotic membrane was separated, and its epithelial base was laid flat on a special surgical membrane paper, and the filter paper with the amniotic membrane adhered to it was cut into clumps of 3cm×3cm or 5cm×5cm size and stored in a sterile bottle of pure glycerin in the refrigerator for 72h below 0℃ and 4℃ for (2) Surgical method: The diseased ocular surface tissue was excised, the dissected surface was rinsed clean with sterile saline containing antibiotics, microscopic sponge forceps and small forceps were used to clean the dissected basal surface, the amniotic membrane was removed from the preservation solution, then the amniotic membrane was peeled off from the filter paper, and glycerol was flushed away with sterile saline. The amniotic membrane is placed on the dissected surface of the eye according to the size of the lesion, with the epithelial side facing up and the basal side facing down, and the excess is cut off. The conjunctival margin and the superficial layer of the outer sclera at the corneal margin were interrupted with 10-0 nylon sutures, and the knot was buried so that the amniotic membrane would adhere to the dissected surface of the lesion as much as possible. After surgery, oxyfloxacin eye ointment was applied and the operated eye was wrapped with a conventional bandage with pressure. Rest flat on the day of surgery and reduce head movement. 2, eyelid closure surgery (tarsorrhaphy) is divided into two kinds of temporary and permanent.