Thigh muscle soreness may be caused by physiological factors such as poor posture while sleeping, and pathologic factors such as lumbar disc herniation. It can be treated by physical therapy such as massage, drug therapy such as non-steroidal anti-inflammatory drugs, and surgery. 1. Physiological factors: such as poor sleeping position, impact, strenuous exercise, etc., can cause thigh muscle pain. You can take proper rest and choose massage, hot compresses and other physical therapy for treatment, in which massage can accelerate blood circulation, accelerate local metabolism, thus reducing the stimulation of lactic acid and other acidic substances on the muscles; hot compresses can accelerate blood circulation and relax the muscles. 2 Lumbar disc herniation: The herniated lumbar disc pressurizes the spinal cord and nerve roots, causing symptoms such as radiating pain and numbness in the lower limbs and soreness in the thigh muscles. Non-steroidal anti-inflammatory drugs such as diclofenac sodium can be used to play an anti-inflammatory role and relieve pain; muscle relaxants such as quaternary arrows of poisonous alkaloids can improve muscle stiffness and other symptoms; surgery can be used to relieve pain and other symptoms if necessary. There are many other causes of thigh muscle soreness, such as myasthenia gravis, which can be treated with cyclophosphamide. It is recommended to consult a doctor in time in order to clarify the cause of the disease and carry out targeted treatment. In addition, all of the above medications should be taken under the guidance of a doctor and should not be used without authorization.