Lateral knee pain can be caused by trauma, arthritis, local infection, lumbar spine disease, etc. General treatment, physical therapy, medication and surgery are feasible. 1. Trauma: Trauma caused by ligament, synovial membrane and other soft tissue injuries can cause lateral pain. It is necessary to fix and elevate the affected limbs, reduce local activities, and take oral analgesic drugs such as Celecoxib as prescribed by doctor, and surgery is needed when the injury is serious. 2. Arthritis: Osteoarthritis of the knee joint caused by age or trauma can cause destruction of articular cartilage, osteomalacia and other lesions, and then pain symptoms. It is necessary to reduce the activities of the knee joint, oral ibuprofen can be used for analgesic treatment, sodium vitrate can be injected into the joint cavity for nutritional softening of the articular cartilage, and surgery is needed for serious cases. 3. Local infection: local soft tissue infection occurring on the side of the knee can cause local swelling and pain. It should be treated with anti-inflammatory and analgesic drugs such as Loxoprofen sodium as prescribed by the doctor, and those with open injuries need to change the medication regularly and use sensitive antibiotic treatment. 4. Lumbar spine disease: lumbar disc herniation can compress the nerves, causing pain and numbness in the innervated area of the knee and other uncomfortable symptoms. You can take methylcobalamin and other nutritive nerve medications as prescribed by your doctor to help restore nerve function, and you can also apply diclofenac sodium and other medications for analgesic treatment. There are many causes of lateral knee pain, including rheumatoid arthritis, meniscus injury, chondromalacia patellae and lateral collateral ligament injury, etc., which should be treated by a doctor in time, and under the guidance of a specialized doctor, appropriate treatments should be carried out, which will help to alleviate the uncomfortable symptoms as soon as possible.