Patients always wake up at two o’clock in the middle of the night belongs to sleep disorder, there are many reasons for its formation, as follows: 1. Psychological factors, psychological factors can account for about 60%-80% of insomnia patients. Patients in life and work, a variety of unpleasant things can lead to emotional anxiety, depression, tension, easy to always wake up at two o’clock in the middle of the night, insomnia. Patients usually demand too much and pay too much attention to certain things, but also affect the mood of patients, leading to patients always waking up at two o’clock in the middle of the night. 2, always waking up at two o’clock in the middle of the night may be related to changes in the patient’s sleep rhythm, that is, the patient’s biological clock disorder, such as frequent changes in the patient’s night shift and day shift can easily lead to always waking up at two o’clock in the middle of the night. 3, disease may lead to patients always waking up at two o’clock in the middle of the night, such as patients with diabetes For example, patients with diabetes always have nighttime hypoglycemia at two o’clock in the night, or when they have gastroduodenal ulcer, they are prone to stomach pain in the middle of the night, resulting in patients always waking up at two o’clock in the night.