There are many types of spots, such as freckles, chloasma, brown spot and nevus, which need to be treated according to specific types, so there is no such thing as the most effective. 1. Freckle: it is a pigmentation spot that occurs on facial skin, which is chromosomally dominant and has no effect on health. Generally, no special treatment is needed, and it is enough to pay attention to sun protection. If it seriously affects the beauty, it can be treated with appropriate topical depigmenting agents, such as hydroquinone cream, arbutin cream, azelaic acid cream, etc. It can also be treated with physical therapy, such as laser therapy, cryotherapy and electrocautery. 2. Melasma: It refers to yellow-brown deposition spots on the face. In daily life, sunlight exposure should be avoided and sunscreen should be applied to reduce melanin production. Hydroquinone cream and arbutin can be used externally for treatment to play the role of decoloration, but it is easy to cause contact dermatitis and other adverse reactions; for some spots that are more generalized, laser and intense pulse light can be used to lighten them. 3. Melanotic nevus: generally related to heredity, belonging to dermal pigmentation increase skin disease, can be lightened by laser. As there are many types of spots, it is recommended that patients first go to the hospital to clarify the type of spots and follow the doctor’s instructions for treatment.