What is dementia in old age?

       Dementia is a generalized impairment of higher cortical activity, which is characterized by gradual memory loss, reduced reasoning and judgment, spatial disorientation, reduced ability to perform activities of daily living, language and social activities, difficulty in acquiring new skills, and the inability to control emotions in a clear state of mind, as well as personality and behavioral changes such as irritability, anxiety, delusions and hallucinations.  Alzheimer’s disease is one of the most common and devastating disorders causing dementia. It is expected to reach 14 million people in the United States alone by the middle of the 21st century, and the number of patients is likely to triple in the next 30-40 years. The huge population base, the aging of our society, and the pursuit of quality of life have led to an increased focus on this disease.  Alzheimer’s disease (also known as Alzheimer’s disease) is a group of degenerative diseases of the central nervous system whose etiology is still unknown t. The main socio-demographic risk factors for its development are: advanced age, female, widowhood, low education and low economic level.  Many scholars have proposed various hypotheses on the etiology and pathogenesis of Alzheimer’s disease, such as: lead poisoning hypothesis, infection hypothesis, endocrine abnormality hypothesis, and molecular genetic studies found that the disease may have genetic heterogeneity, etc. All these hypotheses have yet to be further explored.  Cranial CT, MRI, PET and pathological examination can observe diffuse brain atrophy, enlarged ventricles, widened sulci, massive neuronal loss, and characteristic changes such as senile plaques and neuronal fiber tangles. Some neuromediators associated with learning and memory, such as acetylcholine levels, are also altered.  Alzheimer’s disease often starts in old age or pre-mature old age, with a slow onset and a progressive course. Death from infection failure usually occurs 2 to 8 years after the onset of the disease. The disease often affects work, social activities and family life due to decreased learning and communication skills, confused thinking and lack of logical reasoning.