A urinalysis that shows an increased number of non-squamous epithelial cells may be an increase in urothelial or small round epithelium. If it is simply an increase in the shedding of uroepithelium or small round epithelium, there is no clear clinical significance because a variety of conditions can cause an increase in the shedding of non-squamous epithelial cells in the urinary tract, such as inflammation of the posterior urethra, inflammation of the bladder or excessive exercise, stones or low water intake. Therefore, it needs to be combined with other tests for a comprehensive judgment, such as urological ultrasound, cystoscopy, urine routine, urine culture and other tests to exclude the increase in the number of non-squamous epithelial cells caused by infection, stones, tumors or other causes. The human urinary tract epithelium, there is a normal process of shedding and renewal every day, which is a process of human metabolism. Therefore, a single urine test with an increased number of non-squamous epithelial cells does not have a clear and substantial meaning, but needs to be combined with the patient’s own symptoms and the results of their regular review to make a comprehensive judgment.