The proper way to use Isotretinoin Gel is to clean the affected skin before using the medication and allow it to dry before applying a small amount of the product to the affected area once or twice a day. Isotretinoin Gel is a western medicine used to treat localized acne vulgaris (pimples). Adverse reactions to this medication are a burning sensation, mild to moderate irritation, redness or peeling of the local skin that may occur when starting the medication. Contraindications to the use of the drug are: contraindication to hypersensitivity to the components of the drug, contraindication to pregnant and breastfeeding women, contraindication to patients with a personal or family history of epithelial cell tumors of the skin (skin cancer), contraindication to skin in the area of breakouts, eczema-like or sun-burned areas. This medication is for topical use and should not be taken orally. Avoid lips, mouth, eyes or other mucous membrane areas and the corners of the nose. It should also be used with caution on sensitive areas of the skin, such as the neck. Isotretinoin Gel should be used under the guidance of a medical professional to avoid blind self-medication to avoid adverse reactions.