Gradual elevation of serum α1 microglobulin indicates that there may be renal tubular function impairment, IgA myeloma, hepatocellular carcinoma and other diseases. 1. Impaired renal tubular function: renal tubular function damage caused by interstitial nephritis, glomerulonephritis, hypertension, diabetes mellitus, etc. will show gradual elevation of serum α1microglobulin, which is a sensitive indicator of early proximal renal function damage. 2. IgA myeloma: IgA myeloma will also show gradual increase of serum α1 microglobulin. 3. Hepatocellular carcinoma: α1 microglobulin is synthesized by liver, so when hepatocellular carcinoma occurs, it may also lead to elevation of serum α1 microglobulin. There may be other reasons for the gradual increase of serum α1 microglobulin, so it is recommended to go to the hospital in time to find out the cause of the disease and then target treatment.