Drinking a laxative for two hours without defecation proves that the person concerned is not sensitive to this drug, or the cause is caused by other lesions. It is recommended to go to the hospital for examination, to clarify the cause of the disease, and then treat the cause. You can use laxatives externally under the guidance of a doctor, adopt good living habits, and take surgical treatment in serious cases. 1. External laxatives: People who do not have significant bowel movements with oral laxatives can combine them with external laxatives (e.g., cecroprops, etc.) under the guidance of a doctor. 2. Adopt good living habits: Eat fiber-rich vegetables and fruits, coarse grains and so on in daily life, avoid staying up late, eating a lot of indigestible food, and exercise appropriately. 3. Surgical treatment: constipation caused by organic diseases (such as tumor, intestinal obstruction, etc.) after formal examination requires relevant surgical treatment. The specific situation needs to go to the hospital in time for relevant examination and follow the doctor’s instructions.