Pain below the middle of the chest above the stomach is often associated with esophageal diseases, stomach diseases, heart diseases and other diseases. Patients are advised to visit gastroenterology, cardiology and other departments in a timely manner to clarify the diagnosis and give reasonable treatment to improve the symptoms of chest discomfort. Common causes and treatments are as follows: 1, esophageal diseases: such as esophagitis, gastroesophageal reflux disease, cardia loss of flaccidity and other lesions, can trigger reflux of gastric contents, reflux leads to esophageal mucosa breakage injury, stimulating inflammatory lesions, which can cause patients to have pain below the middle of the chest above the stomach. At this time, the patient is usually also accompanied by acid reflux, bleeding and other symptoms. Should avoid food and drinks that aggravate reflux, such as chocolate, coffee, strong tea, etc., take gastric acid inhibitors and mucosal protective agents, such as omeprazole, cimetidine, aluminum thioglycollate, etc. When combined with infection, antibiotic treatment is required; 2. Stomach diseases: such as chronic gastritis, gastric ulcer, etc. Mostly manifested as upper abdominal discomfort, nausea, vomiting, etc.. Hot compresses can be applied to the abdomen to relieve pain, and oral gastric mucosa protective drugs can be taken under the guidance of a doctor to relieve symptoms, such as aluminum thioglycollate. In case of abdominal distension and other indigestion symptoms, oral gastric stimulants, such as domperidone tablets, can be taken. If there is Helicobacter pylori infection, quadruple therapy treatment needs to be given, i.e. one acid-suppressing drug + two antibiotics + one bismuth agent; 3. Heart disease: such as angina pectoris. When angina attacks, some patients will feel pain below the middle of the chest above the stomach, and radiate to the left shoulder, left arm, left back and other parts. At this time, you should immediately take nitroglycerin under the tongue, if not relieved after 10 minutes, you need to immediately call 120 for emergency. It is recommended to quit smoking and limit alcohol, avoid cold, greasy and irritating food, and exercise in moderation; 4. Other diseases: such as pneumonia, lung tumors, etc. Pneumonia can be manifested as pain below the middle of the chest above the stomach, accompanied by coughing and difficulty in breathing. It is often treated with oral antibiotics, such as amoxicillin, amoxicillin clavulanic acid potassium, etc. If there is a lung tumor, prompt surgical treatment, supplemented by radiotherapy or targeted therapy, is required.