Frequent coughing after falling asleep may be caused by dry environment, asthma, heart failure, gastroesophageal reflux disease, etc., which need to be treated according to the cause. 1. Environmental dryness: A dry indoor environment may result in low humidity in the air, causing some irritation to the throat, which may cause frequent coughing after falling asleep. Treatment can be improved by humidifier to improve the indoor environment and increase the humidity of the environment. 2. Asthma: related to airway hyperreactivity, often in the early hours of the morning or early in the morning attack, can be manifested as paroxysmal cough, chest tightness, wheezing and other symptoms. Commonly used inhaled glucocorticoid combined with β-adrenergic receptor agonist treatment, such as budesonide formoterol powder inhaler. 3. Heart failure: increase in the volume of return blood due to sleep lying down, thus causing pulmonary edema, resulting in frequent coughing at night or accompanied by dyspnea and other symptoms. Diuretics such as furosemide and spironolactone are commonly used to alleviate the symptoms, as well as drugs to enhance cardiac contractility such as digoxin. 4. Gastroesophageal Reflux Disease (GERD): When lying down at night, gastric contents may reflux into the esophagus, pharynx and airway, resulting in frequent coughing at night, heartburn, chest tightness and other symptoms. It is commonly treated with proton pump inhibitors such as omeprazole and gastric motility drugs such as mosapride. Frequent coughing after falling asleep may also be caused by other reasons. If the symptoms are not relieved or aggravated, it is recommended that the patient should go to the hospital in time to improve the examination, clarify the cause of the disease and receive treatment.