The skull is responsible for the protection of the brain, it is like a shield, to maintain the normal operation of all life activities in the skull, but the occurrence of accidents lead to skull defects, the shield is broken, the intracranial tissues are on the verge of danger. It is important to restore the integrity of the skull as soon as possible, and patients should recognize the seriousness of cranial defects and go to the hospital to receive treatment in a timely manner. For the problem of cranial defects, the clinic advocates the improvement of cranial bone repair surgery, which is a classic surgery in neurosurgery, with thousands of years of development history, the technology has become more and more mature, and the repair material has also been constantly replaced and evolved, from the beginning of the bone cement, plexiglass to today’s titanium mesh material and polyetheretherketone peek material, and so on. Will there be any after-effects of cranial repair surgery alone? This is what many patients are worried about, in fact, cranial bone repair surgery process will not involve brain tissue, generally will not produce sequelae. However, if the choice of repair material is not ideal, it does lead to some complications, such as titanium mesh material postoperative infection and rejection of the chances of large, and the affected area is very sensitive to the outside world of the hot and cold environment after the operation, and may even occur in the case of material exposure and so on. Therefore, the key to do skull repair surgery is to choose the right repair material, the material is well chosen the chances of success of the operation is greater, the patient will suffer less. We are now applying the peek material is very good, this is a very safe special polymer materials, peek material stability, good tissue compatibility, high strength, make up for the various shortcomings of the titanium mesh material, postoperative effect is natural and beautiful, good results.