Weliderm is the common name of Tenofovir Tenofovir Fumarate Tablets, this drug can be co-administered with entecavir, but the specific efficacy varies from person to person and it is not possible to assert the effectiveness. Tenofovir disoproxil fumarate is indicated for the treatment of chronic hepatitis B in adults and adolescents (age ≥ 12 years, weight ≥ 35 kg), but this drug is contraindicated in people who are allergic to it, and there may also be headache, diarrhea, and other adverse reactions during the course of the drug. Entecavir, on the other hand, is indicated for chronic adult hepatitis B with active viral replication, persistent elevation of serum alanine aminotransferase, or liver histology showing active lesions, or children aged 2 to 18 years with chronic hepatitis B viral infection in compensated hepatic nucleoside primary treatment, and is also contraindicated in those who are allergic to the drug, and the adverse reactions include headache, vertigo, and so on. There is no contraindication to the combined use of the two drugs, so those who meet the above indications and exclude the relevant contraindications to the use of the drug can be carried out for the combined use of the two drugs. However, the specific efficacy of the drug may vary depending on the patient’s physical condition, dosage, and severity of the disease, so it is not possible to predict the efficacy of the combination of drugs. In conclusion, those who need to take tenofovir disoproxil fumarate tablets in combination with entecavir must take the medication under the guidance of a doctor and closely observe the efficacy of the medication and its reaction, and consult a doctor in a timely manner if any abnormality occurs. Do not blindly use the drug or increase or decrease the dosage on your own, in order to avoid adverse consequences.