Alkaline phosphatase 1888 U/L in a 5-year-old girl, which is significantly higher than the normal range, may be caused by vitamin D insufficiency, or it may be caused by suffering from diseases such as liver or skeletal system. 1. If the child’s intake of vitamin D is insufficient, or the exposure to sunlight is short, the metabolism of calcium and phosphorus may be affected due to insufficient vitamin D in the body and thus high bone alkaline phosphatase may occur. 2. If the child suffers from liver disease, such as cholestatic hepatitis, or suffers from bone disease, such as chondritis, bone tumors, etc., there will be jaundice or bone pain and other corresponding disease manifestations, which will also be accompanied by alkaline phosphatase increased significantly. Therefore, when a girl develops elevated alkaline phosphatase, it is important to take the child to the pediatrics department of the hospital in a timely manner, so that the cause of the disease can be clarified through a complete set of relevant examinations, and appropriate interventions can be given to address the cause of the disease.