There is no basis for the claim that how to treat splenomegaly is the best, patients with splenomegaly first need to clarify the cause of the disease and then treat for the primary disease, common primary diseases include cirrhosis (such as drug treatment), viral hepatitis (antiviral treatment), hemolytic anemia (blood transfusion treatment) and so on. 1. Cirrhosis: (1) Pharmacological treatment: such as the use of anticardiac pain to reduce portal pressure, potassium-preserving diuretics can be applied as well as infusion of albumin for the treatment of ascites, and antimicrobials are suitable for patients with concomitant spontaneous peritonitis. (2) Surgical treatment: abdominal-jugular vein drainage and transjugular intrahepatic porto-caval shunt can effectively reduce portal pressure, and liver transplantation is suitable for patients with end-stage liver disease for whom conventional medical and surgical treatments are ineffective. 2. Viral hepatitis: pay attention to bed rest, reasonable nutrition, ensure the supply of calories, protein and vitamins. Chronic viral hepatitis needs antiviral treatment, commonly used drugs are lamivudine, adefovir and so on. Immunomodulators such as thymosin and immune ribonucleic acid are used. Hepatoprotective drugs such as silymarin and diammonium glycyrrhizinate are used. 3. Hemolytic anemia: medication can be used mainly glucocorticoids and immunosuppressants. Blood transfusion can temporarily improve the patient’s condition, but the indications for blood transfusion should be strictly controlled. Splenectomy is suitable for hereditary spherocytosis, autoimmune hemolytic anemia and partial marine anemia, and the symptoms can be reduced after splenectomy. If you have any uncomfortable symptoms, you need to go to the hospital as soon as possible, and the doctor will formulate an individualized diagnosis and treatment plan according to your specific condition, so as to avoid delaying your condition.