The skin of the nasal vestibule can be disinfected with iodophor, but the mucous membrane inside the nasal cavity cannot be disinfected with iodophor. The epithelium of the nasal mucosa has the role of ventilation, cleaning and filtering the air inhaled from outside, heating and humidifying the dry and cold air inhaled, and the nasal mucosa has important physiological functions such as reflex and olfaction. The intact epithelial structure of the nasal mucosa constitutes the first mechanical defense barrier of the respiratory tract. Iodophor has an irritating effect on the mucosa, which can cause irreversible damage to the nasal mucosa and lead to hyposmia or loss of sense of smell, retention of nasal secretions causing postnasal drip and other diseases. Iodophor is a topical medication. Iodophor disinfectant is mainly used for skin disinfection, as well as for disinfection of the skin at the surgical site during surgery, and as a pre-surgical hand-brushing disinfection treatment for the surgeon. Iodophor disinfects well and is relatively mildly irritating to skin wounds, but has a significant irritating effect on mucous membranes.