The best time to take progesterone during pregnancy is in the early stages of pregnancy. Progesterone is a very important hormone for pregnant women, and if the level of progesterone is too low, it can increase the risk of miscarriage and embryonic abortion. Progesterone is recommended in early pregnancy, for pregnant women with symptoms of preterm miscarriage, or for pregnant women with low progesterone. Progesterone is an oil, choose bilateral gluteal intramuscular injection, during the injection process, there will be a sore and swollen feeling in the buttocks, which will be slowly relieved after the injection is finished. However, although progesterone has a fetal preservation effect, it is not recommended for all pregnant women to use it routinely, or only with indications to progesterone.