Hypophosphatasia can cause neuromuscular symptoms such as anorexia, dizziness, muscle weakness, etc. In serious cases, coma, neurological disorders, convulsions and even death can occur. Experts pointed out that hypophosphatasia is a symptom that is very harmful to the patient’s body, patients need to go to a regular professional hospital for diagnosis and treatment, so as to ensure the effectiveness of treatment. Causes of low blood phosphorus: 1, alkalosis Acute respiratory alkalosis and metabolic alkalosis can reduce blood phosphorus, but respiratory alkalosis is more obvious. In respiratory alkalosis, the decrease in intracellular CO2 leads to an increase in intracellular pH, the latter stimulates the glycolytic pathway, especially the activation of the key rate-limiting enzyme of glycolysis —- phosphofructokinase, and the increase in the products of glycophosphorylation drives serum phosphorus into the cells and increases the intake of phosphorus by the muscles, leading to hypophosphatemia. For example, 2 to 10 days after severe burns, as exhalation of alkali can lead to hypophosphatemia. Other diseases related to hyperventilation, such as sepsis, myocardial infarction and hepatic coma, can also cause hypophosphatemia. 2, acidosis acidosis, especially diabetic ketoacidosis, can reduce the enzymatic effect of glucose, thereby increasing the concentration of serum phosphate, strengthen the urinary phosphorus excretion, but also due to a serious reduction in the use of intracellular phosphorus, or even completely stop, and the number of intracellular anions increased significantly, followed by phosphorus will move out of the cells, through the kidney excretion, resulting in hypophosphatemia. 3, serious infections bacterial toxins can also reduce blood phosphorus, bacteria, mainly gram-negative bacteria, endotoxin can cause disorders of carbohydrate metabolism, blocking the phosphorus metabolic pathway, so that the blood phosphorus concentration is reduced. The mechanism may also be related to the role of cytokines, Barak et al. reported that in patients with severe infections and sepsis, high levels of cytokines in the blood (mainly IL-6 and TNF-a) are closely related to the decrease in blood phosphorus. 4, stress state Under the stimulation of trauma, surgery, infection and other factors, the body produces stress, increased secretion of pro-catabolic hormones, such as catecholamines, glucocorticoids, hyperglycemia, thyroxine, etc., resulting in accelerated protein and fat decomposition, gluconeogenesis, increased hepatic glucose production, increased blood glucose, so that the body is in a high catabolic state, resulting in redistribution of phosphorus in the body, increased urinary phosphorus excretion, and decreased blood phosphorus.