Diseases that cause non-squamous edema of the legs are relatively rare, and are more commonly seen in hypothyroidism, and obstructed lymphatic reflux due to filariasis. Non-squamous edema of the legs is mainly seen in mucous edema due to hypothyroidism. When too little thyroid hormone is secreted, protein synthesis is impaired, and interstitial mucin is deposited in the tissues, causing water molecules to be trapped under the skin and causing mucous edema. Patients may also experience symptoms such as fear of cold, slowness of movement, easy fatigue, and dry skin. Filariasis, on the other hand, causes non-squamous edema of the legs by blocking lymphatic vessels, causing obstruction of lymphatic return. If non-squamous edema occurs in the legs, it is recommended that the patient consult a doctor in a timely manner to clarify the cause of the disease and then carry out targeted treatment to avoid delaying the disease.