Gallstones may cause transaminase elevation. 1. In the process of gallstone removal, the stone passes through the bile duct and causes damage to the bile duct cells, resulting in abnormal liver function, which may cause transaminase elevation, and bile duct obstruction may also cause elevated bilirubin levels. 2. Gallstones often lead to repeated obstruction of the cystic duct, bile can not be discharged in a timely manner, retention occurs, may also cause transaminase elevation. Gallstones patients with elevated aminotransferases should seek medical attention in a timely manner, and cholecystectomy may be required if necessary. In addition, elevated aminotransferases may also be caused by other liver and gallbladder diseases, and the cause should be identified and treated.