Patients with high creatinine are not recommended to eat tofu, high creatinine indicates that the patient may have chronic renal failure. Patients with chronic renal failure should have a low-salt, low-fat, high-quality low-protein diet. Low-salt means eating less pickled things, and low-fat means eating less cholesterol and fat-rich foods. High-quality protein is high bioavailability protein, mainly animal protein, such as fish and eggs. Avoid foods rich in plant protein, because plant protein contains less amount of essential amino acids and more metabolic waste can increase the burden on the kidneys. Tofu is rich in vegetable protein, so it cannot be eaten. Chronic renal failure is not treated with any specific drugs in current medicine, mainly to slow down the progress of renal function, protect the residual renal function, and avoid nephrotoxic drugs. Actively control blood pressure, reduce proteinuria, actively correct anemia, maintain water-electrolyte and acid-base balance, but also actively treat various complications of chronic renal failure. If the patient has symptoms of uremia, such as poor appetite, nausea, vomiting, chest tightness, shortness of breath, dyspnea, heart failure, anemia aggravated and difficult to correct, recurrent infections as well as uremic encephalopathy manifestations need renal replacement therapy, currently there are hemodialysis and peritoneal dialysis.