Kidney stone 5x4mm treatment includes general treatment, medication, and if there are indications for surgery, surgery can be chosen if necessary. 1. General treatment: For kidney stones 5x4mm in size, without obvious infection, patients are advised to maintain sufficient water intake and walk appropriately to promote the discharge of stones. 2. Drug treatment: when the patient has obvious pain, you can follow the doctor’s instructions to choose pain medication, common drugs are indomethacin, ibuprofen and so on. If the spasm of ureter, you can also give atropine sulfate, scopolamine and other drugs to relieve spasm, you can also give sodium bicarbonate tablets to alkalize the urine, accelerate the discharge of uric acid. 3. Surgical treatment: surgical treatment if the diameter of the stone as a basis for judgment, generally the diameter is greater than 1cm priority for surgical treatment. However, patients with 5x4mm stones, combined with serious obstruction and infection, need to take timely treatment, common surgical methods include extracorporeal shock wave lithotripsy, percutaneous nephrolithotripsy. To summarize, about how to treat kidney stones 5x4mm, there is also a large individual variability, it is recommended that the patient timely medical treatment, follow the doctor’s prescription medication.