Symptoms of worsening of lung adenocarcinoma in advanced stage include worsening of respiratory symptoms, symptoms of metastatic foci and symptoms of unstable vital signs. 1. Worsening of respiratory symptoms, patients with lung adenocarcinoma may have serious difficulty in breathing, can not lie down at night, severe cough, hemoptysis or severe chest pain. 2. Symptoms of metastatic foci include severe headache, projectile vomiting, impaired limb movement caused by brain metastasis, etc., and symptoms of abdominal distension, great reduction of food intake, yellowing of skin and mucous membrane of the whole body caused by liver metastasis. 3. Symptoms of unstable vital signs, such as drop in blood pressure, intermittent respiratory arrest, cardiac arrhythmia or slow heart rate, high body temperature or hypothermia. If you suspect that your condition is worsening, you should consult a doctor.