Renal clear cell carcinoma grade 3 is more serious, representing lower differentiation and higher malignancy, which can reflect one aspect of the severity of the disease, and the overall assessment should also consider other factors such as tumor stage and patient’s physical condition. Renal clear cell carcinoma belongs to malignant tumors, and grade 3 is more serious as it represents obvious heterogeneity of cancer cells, lower differentiation, higher malignancy and higher potential of local infiltration and distant metastasis. Comprehensive evaluation of disease severity should also consider other factors such as tumor stage and patient’s physical condition, for example, advanced renal clear cell carcinoma grade 3 is more serious than early stage renal clear cell carcinoma grade 3, and patients with poor physical condition of the same stage of renal clear cell carcinoma grade 3 are more serious than patients with better physical condition. Therefore, renal clear cell carcinoma grade 3 is more serious, and it is recommended to have comprehensive assessment and judgment under the guidance of doctor.