Radiofrequency thermotherapy equipment is widely used in systemic and local superficial and deep primary, recurrent malignant solid tumors or metastatic tumor suitability, which can completely solve the phenomenon of fat sclerosis that is very easy to appear in patients’ radiofrequency thermotherapy and can reach the depth treatment temperature. First, what is thermotherapy? Thermotherapy is the 5th tumor treatment means after surgery, radiotherapy, chemotherapy and biotherapy, and it is also one of the important adjuvant treatments for tumors. It is non-toxic and safe in clinical application, and it is called green treatment. The concept of tumor thermotherapy used more often in clinic refers to the application of different physical factors (radiofrequency, microwave, ultrasound and laser, etc.) to increase the temperature of tumor tissues and/or the whole body, and the use of high temperature to kill and treat tumors and its secondary effects. Second, will it cause damage to normal tissues? After heating, normal tissues will experience vasodilatation and accelerated blood flow, and the heat dissipation effect will be enhanced. Some data show that when it reaches 41.5~43℃, the tissue damage is not big and can be repaired. However, this is not the case for tumor tissues, where blood vessels within the tumor have an abnormal morphology, are messy and twisted, easily deformed by pressure, and form thrombi or embolism. In addition, the blood vessels within the tumor are mostly composed of monolayer cells, which are fragile and easily broken. As these neovascularization is underdeveloped deformed blood vessels, they lose self-regulation after being heated, and the veins can not speed up the reflux, the local blood stagnation of the tumor, and the blood flow is only 1%~15% of the normal tissues, which results in the difficulty of heat dissipation of the tumor tissues, and the temperature rises, and the heat can easily be accumulated in the tumor tissues, and it is precisely because of the difference of the temperature between the tumor tissues and the normal tissues that makes the tumor hyperthermia become a possibility. It is because of the temperature difference between tumor tissue and normal tissue that makes tumor thermotherapy a possibility, so the concern about the damage to normal tissue is unnecessary. What are the clinical applications of thermotherapy? In clinical practice, thermotherapy is seldom used as a single treatment modality, it is mostly combined with other treatment modalities to enhance the effect; for example, combined with chemotherapy, radiotherapy and immunotherapy. Heat therapy can be used for those tumor patients? 1.Superficial tumors 1) Skin cancer in all parts of the body, including squamous cell carcinoma, adenocarcinoma and melanoma. (2) Metastatic cancer in superficial lymph nodes of the whole body, such as neck, supraclavicular region, axilla and groin. 3) Malignant tumors of superficial organs and limbs: a) more superficial primary tumors of the head and neck, such as cancers of the lips, gums, buccal mucosa, face, scalp, and auricle; b) cancers of the vulva and anus; c) tumors of the limbs, such as soft-tissue sarcoma [and osteosarcoma; d) breast cancer. 4) recurrent or metastatic tumors located on the body surface. 2. Cavitary tumors Nasopharyngeal cancer, esophageal cancer, cervical cancer and rectal cancer. 3.Malignant pleural effusion, abdominal effusion and so on. V. Contraindications to thermotherapy 1. Absolute contraindications: Pregnant women and patients without autonomous expression ability; patients with organic central nervous system disease, malignant disease, serious disturbance of water and electrolyte, serious cardiopulmonary insufficiency; patients who cannot tolerate heating therapy with serious infection; patients who have heat-accumulating metal implants and pacemakers in the body; patients with infectious diseases, such as active syphilis and active tuberculosis; patients with mental diseases; patients with body perception disorder; and patients with tendency to bleed. Those who have bleeding tendency. Relative contraindications Brain metastasis with neurological symptoms; coronary heart disease; abdominal subcutaneous fat is too thick; skin infection and ulceration at the site of hyperthermia treatment; women’s menstruation. Sixth, when can heat therapy intervention? 1.Combined neoadjuvant chemotherapy 2.Combined chemotherapy 3.Intraoperative hyperthermia